Hi, my name is

Daniel Crocker.

Biomedical Engineering | University of Minnesota

Building at the intersection of biology and computation.

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01

About Me

Daniel Crocker
Minneapolis, MN

I'm a sophomore Biomedical Engineering student in the Honors Program at the University of Minnesota, with an interest in the intersection of computational biology and machine learning. Currently at the Hackel Lab, I'm building StructVar-Bench, a pathogenicity prediction benchmark for missense mutations; it fuses protein structure, thermodynamics, and protein language models into graph neural networks, reaching 0.9232 AUC-ROC.

I also design adversarial evaluations that probe the reasoning limits of frontier AI models at Handshake AI. Previously, I built a hybrid brain-computer interface that earned 1st place at the Twin Cities Regional Science Fair and qualified for ISEF. Outside the lab, I've contributed 300+ volunteer hours, consulted for Thermo Fisher Scientific, and sharpened journalistic writing as a copy editor.

I'm passionate about developing innovations where biology and engineering intersect that can make a real difference in people's lives.

0
GPA
Top 1%
National Merit Semifinalist
1st
Regional Science Fair & ISEF Qualifier
0+
Volunteer Hours
02

Experience

Mar 2026 – Present

Hackel Lab

Independent Researcher · University of Minnesota

Building StructVar-Bench: a multi-modal structural dataset and benchmark for missense variant pathogenicity prediction. Integrated ClinVar, UniProt, and AlphaFold data across ~89,000 variants, modeled mutation energetics with large-scale FoldX ΔΔG calculations, and trained graph neural networks in PyTorch Geometric to 0.9232 AUC-ROC.

Read the full case study →
Oct 2025 – Present

Handshake AI

AI Model Evaluation Specialist · Remote

Design adversarial evaluation tasks across text, image, audio, and video that expose reasoning failures in leading AI models. Build stumping multimodal problems — verifying ground truth and analyzing failures across counting, spatial reasoning, extraction, and cross-panel synthesis — and review model outputs for truthfulness, correctness, and instruction following.

Sep 2024 – Jun 2025

Minnetonka Research Program

Researcher & Competitor · Independent Research

Developed a hybrid EEG + eye-tracking brain-computer interface with continuous learning, improving rolling command accuracy to 75–80% over 36 retraining loops for adaptive assistive robotic control. 1st Place in Biomedical Engineering at the Twin Cities Regional Science Fair; ISEF qualifier.

Jan – Jun 2024

Thermo Fisher Scientific

Student Consultant · VANTAGE Program

Assessed cybersecurity practices for Thermo Fisher's biomedical product line through stakeholder interviews, competitor benchmarking, and regulatory analysis. Delivered recommendations on legacy product replacement, customer cybersecurity education, and ongoing monitoring.

Oct – Dec 2023

Peak Performance Twin Cities

Student Consultant · VANTAGE Program

Provided data-driven hiring recommendations through quantitative and qualitative analysis. Collaborated with team members to present findings and deliver well-rounded strategic solutions.

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Research

0.9232 AUC-ROC

StructVar-Bench

Hackel Lab · University of Minnesota

A multi-modal structural dataset and benchmark for missense variant pathogenicity prediction. Built ~89,000 missense variants from ClinVar, UniProt, and AlphaFold; modeled energetics with large-scale FoldX ΔΔG; and fused structure with ESM-2 protein-language embeddings in graph neural networks, lifting AUC-ROC from 0.87 (structure-only) to 0.9232.

Python PyTorch Geometric FoldX AlphaFold ESM-2 GNN
Read the full case study →
1st Place · ISEF Qualifier

Hybrid Brain-Computer Interface

Minnetonka Research Program · Independent Research

Hybrid brain-computer interface with continuous learning and eye-tracking for adaptive mental command control. Developed a hybrid model integrating EEG-based mental command training with eye-tracking to improve accuracy and adaptability in assistive robotic control. Competed at Twin Cities and Minnesota State Science & Engineering Fairs.

EEG EMOTIV Eye-Tracking Python Machine Learning
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Skills

Physics
Technical
Engineering
Languages
Professional
Laboratory
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Get In Touch

I'm always open to discussing research collaborations, new opportunities, or interesting problems at the intersection of biology and technology.